Conversion of graded to binary response in an activator-repressor system
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چکیده
منابع مشابه
Conversion of graded to binary response in an activator-repressor system.
Appropriate regulation of gene expression is essential to ensure that protein synthesis occurs in a selective manner. The control of transcription is the most dominant type of regulation mediated by a complex of molecules such as transcription factors. In general, regulatory molecules are of two types: activator and repressor. Activators promote the initiation of transcription whereas repressor...
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Conversion of the Vibrio fischeri transcriptional activator, LuxR, to a repressor.
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We study the response of an autoregulated gene to a range of concentrations of signal molecules. We show that transcriptional leakage and noise due to translational bursting have the opposite effects. In a positively autoregulated gene, increasing the noise converts the response from graded to binary, while increasing the leakage converts the response from binary to graded. Our findings support...
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ژورنال
عنوان ژورنال: Physical Review E
سال: 2010
ISSN: 1539-3755,1550-2376
DOI: 10.1103/physreve.81.021905